TẠP CHÍ KHOA HỌC YERSIN

YERSIN JOURNAL OF SCIENCE

ISSN: 2525 - 2372

TIỀM NĂNG ỨNG DỤNG CỦA CÁC HỢP CHẤT HOẠT TÍNH SINH HỌC TỪ TẢO LỤC

Tóm tắt

Tảo biển được biết đến vì giàu polysaccharide, khoáng chất và một số vitamin, chúng cũng chứa các chất hoạt tính sinh học có đặc tính kháng khuẩn, kháng virus…. Điều này mang lại cho tảo biển tiềm năng lớn trong việc sử dụng làm thực phẩm bổ sung trong thực phẩm chức năng hoặc chiết xuất các hợp chất. Tảo lục có đặc điểm chủ yếu là chất diệp lục (chlorophyll), một sắc tố hòa tan trong lipid màu xanh lục thường được tìm thấy trong thực vật, tảo và vi khuẩn lam. Chất diệp lục đóng vai trò quan trọng trong quá trình quang hợp và một số chức năng sinh học. Bài tổng quan này tóm tắt dữ liệu khoa học về thành phần sinh hóa và hoạt tính sinh học của các hợp chất trong tảo biển, đặc biệt là tảo lục và một số trường hợp nghiên cứu sẽ được phân tích để chứng minh tác dụng có lợi của các hợp chất tảo biển đối với sức khỏe con người. Thông tin thu thập để  tổng hợp đã được tìm kiếm bằng cách sử dụng công cụ tìm kiếm phổ biến như Google Scholar, PubMed,….

Abstract

Seaweed is known for being rich in polysaccharides, minerals and some vitamins. They also contain bioactive compounds with antibacterial, antiviral properties, etc. This gives seaweed great potential for being used as a food supplement in functional foods or for extracting compounds. Green algae are primarily characterized by chlorophyll, a green lipid-soluble pigment commonly found in plants, algae and cyanobacteria. Chlorophyll plays an important role in photosynthesis and several biological functions. This review summarizes scientific data on the biochemical compositions and biological activity of compounds in seaweed, especially green algae, and a number of case studies will be analyzed to demonstrate their beneficial effects of seaweed compounds for human health. Collected information for synthesis was found by using popular search engines such as Google Scholar, PubMed, etc.

Từ khóa

Chlorophyta, hoạt tính sinh học, tảo biển lớn, tảo lục, ứng dụng

Chlorophyta, application, bioactive properties, green algae, macroalgae

Tài liệu tham khảo

Agbaje-Daniels, F. ., Adeleye, A. ., Nwankwo, D. ., Adeniyi, B. ., Seku, F. ., & Beukes, D. (2020). Antibacterial Activities of Selected Green Seaweeds fromWest African Coast. Ec Pharmacol. Toxicol., 4, 84–92.

Al-Adilah, H., Al-Sharrah, T. K., Al-Bader, D., Ebel, R., Küpper, F. C., & Kumari, P. (2021). Assessment of arabian gulf seaweeds from kuwait as sources of nutritionally important polyunsaturated fatty acids (Pufas). Foods, 10(10), 1–17. https://doi.org/10.3390/foods10102442

Alves, A., Sousa, R. A., & Reis, R. L. (2013). In Vitro Cytotoxicity Assessment of Ulvan, a Polysaccharide Extracted from Green Algae. Phytotherapy Research, 27(8), 1143–1148. https://doi.org/10.1002/ptr.4843

Arumugam, N., Chelliapan, S., Kamyab, H., Thirugnana, S., Othman, N., & Nasri, N. (2018). Treatment of Wastewater Using Seaweed: A Review. International Journal of Environmental Research and Public Health, 15(12), 2851. https://doi.org/10.3390/ijerph15122851

Aryee, A. N., Agyei, D., & Akanbi, T. O. (2018). Recovery and utilization of seaweed pigments in food processing. Current Opinion in Food Science, 19, 113–119. https://doi.org/10.1016/j.cofs.2018.03.013

Baweja, P., Kumar, S., Sahoo, D., & Levine, I. (2016). Biology of Seaweeds. In Seaweed in Health and Disease Prevention (pp. 41–106). Elsevier. https://doi.org/10.1016/B978-0-12-802772-1.00003-8

Bedoux, G., Hardouin, K., Burlot, A. S., & Bourgougnon, N. (2014). Bioactive components from seaweeds: Cosmetic applications and future development. In E. Bourgougnon (Ed.), Advances in Botanical Research (pp. 345–378). Elsevier. https://doi.org/https://doi.org/10.1016/B978-0-12- 408062-1.00012-3

Berri, M., Olivier, M., Holbert, S., Dupont, J., Demais, H., Le Goff, M., & Collen, P. N. (2017). Ulvan from Ulva armoricana (Chlorophyta) activates the PI3K/Akt signalling pathway via TLR4 to induce intestinal cytokine production. Algal Research, 28(April), 39–47. https://doi.org/10.1016/j.algal.2017.10.008

Biancarosa, I., Belghit, I., Bruckner, C. G., Liland, N. S., Waagbø, R., Amlund, H., Heesch, S., & Lock, E. (2018). Chemical characterization of 21 species of marine macroalgae common in Norwegian waters: benefits of and limitations to their potential use in food and feed. Journal of the Science of Food and Agriculture, 98(5), 2035–2042. https://doi.org/10.1002/jsfa.8798

Bitencourt, M. A. O., Silva, H. M. D., Abílio, G. M. F., Miranda, G. E. C., Moura, A. M. A., de Araújo-Júnior, J. X., Silveira, E. J. D., Santos, B. V. O., & Souto, J. T. (2015). Anti-inflammatory effects of methanolic extract of green algae Caulerpa mexicana in a murine model of ulcerative colitis. Revista Brasileira de Farmacognosia, 25(6), 677–682. https://doi.org/10.1016/j.bjp.2015.10.001

Canché Chay, C. I., Cansino, R. G., Espitia Pinzón, C. I., Torres-Ochoa, R. O., & Martínez, R. (2014). Synthesis and anti-tuberculosis activity of the marine natural product caulerpin and its analogues. Marine Drugs, 12(4), 1757–1772. https://doi.org/10.3390/md12041757

Celikler, S., Tas, S., Vatan, O., Ziyanok-Ayvalik, S., Yildiz, G., & Bilaloglu, R. (2009). Anti-hyperglycemic and antigenotoxic potential of Ulva rigida ethanolic extract in the experimental diabetes mellitus. Food and Chemical Toxicology, 47(8), 1837–1840. https://doi.org/10.1016/j.fct.2009.04.039

Cherry, P., O’Hara, C., Magee, P. J., McSorley, E. M., & Allsopp, P. J. (2019). Risks and benefits of consuming edible seaweeds. Nutrition Reviews, 77(5), 307–329. https://doi.org/10.1093/nutrit/nuy066

Circuncisão, A., Catarino, M., Cardoso, S., & Silva, A. (2018). Minerals from Macroalgae Origin: Health Benefits and Risks for Consumers. Marine Drugs, 16(11), 400. https://doi.org/10.3390/md16110400

Cofrades, S., Benedí, J., Garcimartin, A., Sánchez-Muniz, F. J., & Jimenez-Colmenero, F. (2017). A comprehensive approach to formulation of seaweed-enriched meat products: From technological development to assessment of healthy properties. Food Research International, 99, 1084–1094. https://doi.org/10.1016/j.foodres.2016.06.029

Cotas, J., Pacheco, D., Gonçalves, A. M. M., Silva, P., Carvalho, L. G., & Pereira, L. (2021). Seaweeds’ nutraceutical and biomedical potential in cancer therapy: a concise review. Journal of Cancer Metastasis and Treatment, 2021. https://doi.org/10.20517/2394-4722.2020.134

De Souza, É. T., De Lira, D. P., De Queiroz, A. C., Da Silva, D. J. C., De Aquino, A. B., Campessato Mella, E. A., Lorenzo, V. P., De Miranda, G. E. C., De Araújo-Júnior, J. X., De Oliveira Chaves, M. C., Barbosa-Filho, J. M., De Athayde-Filho, P. F., De Oliveira Santos, B. V., & Alexandre-Moreira, M. S. (2009). The antinociceptive and anti-inflammatory activities of caulerpin, a bisindole alkaloid isolated from seaweeds of the genus Caulerpa. Marine Drugs, 7(4), 689–704. https://doi.org/10.3390/md7040689

Fleurence, J., Morançais, M., & Dumay, J. (2018). Seaweed proteins. In Proteins in Food Processing (pp. 245–262). Elsevier. https://doi.org/10.1016/B978-0-08-100722-8.00010-3

Furuta, T., Miyabe, Y., Yasui, H., Kinoshita, Y., & Kishimura, H. (2016). Angiotensin I Converting Enzyme Inhibitory Peptides Derived from Phycobiliproteins of Dulse Palmaria palmata. Marine Drugs, 14(2), 32. https://doi.org/10.3390/md14020032

Gnanavel, V., Roopan, S. M., & Rajeshkumar, S. (2019). Aquaculture: An overview of chemical ecology of seaweeds (food species) in natural products. Aquaculture, 507, 1–6. https://doi.org/10.1016/j.aquaculture.2019.04.004

Gómez-Guzmán, M., Rodríguez-Nogales, A., Algieri, F., & Gálvez, J. (2018). Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders. Marine Drugs, 16(8), 250. https://doi.org/10.3390/md16080250

Gosch, B. J., Magnusson, M., Paul, N. A., & de Nys, R. (2012a). Total lipid and fatty acid composition of seaweeds for the selection of species for oil-based biofuel and bioproducts. GCB Bioenergy, 4(6), 919–930. https://doi.org/10.1111/j.1757-1707.2012.01175.x

Gosch, B. J., Magnusson, M., Paul, N. A., & de Nys, R. (2012b). Total lipid and fatty acid composition of seaweeds for the selection of species for oil‐based biofuel and bioproducts. GCB Bioenergy, 4(6), 919–930. https://doi.org/10.1111/j.1757-1707.2012.01175.x

Gullón, B., Gagaoua, M., Barba, F. J., Gullón, P., Zhang, W., & Lorenzo, J. M. (2020). Seaweeds as promising resource of bioactive compounds: Overview of novel extraction strategies and design of tailored meat products. Trends in Food Science & Technology, 100, 1–18. https://doi.org/10.1016/j.tifs.2020.03.039

Hentati, F., Delattre, C., Ursu, A. V., Desbrières, J., Le Cerf, D., Gardarin, C., Abdelkafi, S., Michaud, P., & Pierre, G. (2018). Structural characterization and antioxidant activity of water-soluble polysaccharides from the Tunisian brown seaweed Cystoseira compressa. Carbohydrate Polymers, 198, 589–600. https://doi.org/10.1016/j.carbpol.2018.06.098

Hentati, F., Tounsi, L., Djomdi, D., Pierre, G., Delattre, C., Ursu, A. V., Fendri, I., Abdelkafi, S., & Michaud, P. (2020). Bioactive Polysaccharides from Seaweeds. Molecules, 25(14), 3152. https://doi.org/10.3390/molecules25143152

Jesumani, V., Du, H., Aslam, M., Pei, P., & Huang, N. (2019). Potential Use of Seaweed Bioactive Compounds in Skincare—A Review. Marine Drugs, 17(12), 688. https://doi.org/10.3390/md17120688

Jiménez-Escrig, A., Gómez-Ordóñez, E., & Rupérez, P. (2011). Seaweed as a Source of Novel Nutraceuticals. Advances in Food and Nutrition Research, 325–337. https://doi.org/10.1016/B978-0-12-387669-0.00026-0

K, I., S, B., M, S., S, B., & T, B. (2013). Evaluation of in vitro antimicrobial property of seaweed (Halimeda tuna) from Tuticorin coast, Tamil Nadu, Southeast coast of India. African Journal of Biotechnology, 12(3), 284–289. https://doi.org/10.5897/AJB12.014

Kendel, M., Wielgosz-Collin, G., Bertrand, S., Roussakis, C., Bourgougnon, N., & Bedoux, G. (2015). Lipid Composition, Fatty Acids and Sterols in the Seaweeds Ulva armoricana, and Solieria chordalis from Brittany (France): An Analysis from Nutritional, Chemotaxonomic, and Antiproliferative Activity Perspectives. Marine Drugs, 13(9), 5606–5628. https://doi.org/10.3390/md13095606

Klnc, B., Cirik, S., Turan, G., Tekogul, H., & Koru, E. (2013). Seaweeds for Food and Industrial Applications. In I. Muzzalupo (Ed.), Food Industry. InTech. https://doi.org/10.5772/53172

Kumar, M., Kumari, P., Trivedi, N., Shukla, M. K., Gupta, V., Reddy, C. R. K., & Jha, B. (2011). Minerals, PUFAs and antioxidant properties of some tropical seaweeds from Saurashtra coast of India. Journal of Applied Phycology, 23(5), 797–810. https://doi.org/10.1007/s10811-010-9578-7

Lakshmi, D. S., Sankaranarayanan, S., Gajaria, T. K., Li, G., Kujawski, W., Kujawa, J., & Navia, R. (2020). A short review on the valorization of green seaweeds and ulvan: Feedstock for chemicals and biomaterials. Biomolecules, 10(7), 1–20. https://doi.org/10.3390/biom10070991

Lomartire, S., & Gonçalves, A. M. M. (2022). An Overview of Potential Seaweed-Derived Bioactive Compounds for Pharmaceutical Applications. In Marine Drugs (Vol. 20, Issue 2). https://doi.org/10.3390/md20020141

Lorenzo, J., Agregán, R., Munekata, P., Franco, D., Carballo, J., Şahin, S., Lacomba, R., & Barba, F. (2017). Proximate Composition and Nutritional Value of Three Macroalgae: Ascophyllum nodosum, Fucus vesiculosus and Bifurcaria bifurcata. Marine Drugs, 15(11), 360. https://doi.org/10.3390/md15110360

Lucena, A. M. M., Souza, C. R. M., Jales, J. T., Guedes, P. M. M., De Miranda, G. E. C., de Moura, A. M. A., Araújo-Júnior, J. X., Nascimento, G. J., Scortecci, K. C., Santos, B. V. O., & Souto, J. T. (2018). The bisindole alkaloid caulerpin, from seaweeds of the genus Caulerpa, attenuated colon damage in murine colitis model. Marine Drugs, 16(9), 1–18. https://doi.org/10.3390/md16090318

Luo, X., Su, P., & Zhang, W. (2015). Advances in Microalgae-Derived Phytosterols for Functional Food and Pharmaceutical Applications. Marine Drugs, 13(7), 4231–4254. https://doi.org/10.3390/md13074231

Macedo, N. R. P. V., Ribeiro, M. S., Villaça, R. C., Ferreira, W., Pinto, A. M., Teixeira, V. L., Cirne-Santos, C., Paixão, I. C. N. P., & Giongo, V. (2012). Caulerpin as a potential antiviral drug against herpes simplex virus type 1. Revista Brasileira de Farmacognosia, 22(4), 861–867. https://doi.org/10.1590/S0102-695X2012005000072

Madub, K., Goonoo, N., Gimié, F., Ait Arsa, I., Schönherr, H., & Bhaw-Luximon, A. (2021). Green seaweeds ulvan-cellulose scaffolds enhance in vitro cell growth and in vivo angiogenesis for skin tissue engineering. Carbohydrate Polymers, 251, 117025. https://doi.org/10.1016/j.carbpol.2020.117025

Mahadevan, K. (2015). Seaweeds: a sustainable food source. In Seaweed Sustainability (pp. 347–364). Elsevier. https://doi.org/10.1016/B978-0-12-418697-2.00013-1

Makkar, H. P. S., Tran, G., Heuzé, V., Giger-Reverdin, S., Lessire, M., Lebas, F., & Ankers, P. (2016). Seaweeds for livestock diets: A review. Animal Feed Science and Technology, 212, 1–17. https://doi.org/10.1016/j.anifeedsci.2015.09.018

Montero, L., del Pilar Sánchez-Camargo, A., Ibáñez, E., & Gilbert-López, B. (2019). Phenolic Compounds from Edible Algae: Bioactivity and Health Benefits. Current Medicinal Chemistry, 25(37), 4808–4826. https://doi.org/10.2174/0929867324666170523120101

Morais, T., Cotas, J., Pacheco, D., & Pereira, L. (2021). Seaweeds Compounds: An Ecosustainable Source of Cosmetic Ingredients? Cosmetics, 8(1), 8. https://doi.org/10.3390/cosmetics8010008

Pal, A., Kamthania, M. C., & Kumar, A. (2014). Bioactive Compounds and Properties of Seaweeds—A Review. OALib, 01(04), 1–17. https://doi.org/10.4236/oalib.1100752

Pérez-López, P., Balboa, E. M., González-García, S., Domínguez, H., Feijoo, G., & Moreira, M. T. (2014). Comparative environmental assessment of valorization strategies of the invasive macroalgae Sargassum muticum. Bioresource Technology, 161, 137–148. https://doi.org/10.1016/j.biortech.2014.03.013

Pinto, A. M. V., Leite, J. P. G., Ferreira, W. J., Cavalcanti, D. N., Villaça, R. C., Giongo, V., Teixeira, V. L., & Paixão, I. C. N. de P. (2012). Marine natural seaweed products as potential antiviral drugs against bovine viral diarrhea virus. Revista Brasileira de Farmacognosia, 22(4), 813–817. https://doi.org/10.1590/S0102-695X2012005000060

Reis, S. E., Andrade, R. G. C., Accardo, C. M., Maia, L. F., Oliveira, L. F. C., Nader, H. B., Aguiar, J. A. K., & Medeiros, V. P. (2020). Influence of sulfated polysaccharides from Ulva lactuca L. upon Xa and IIa coagulation factors and on venous blood clot formation. Algal Research, 45, 101750. https://doi.org/10.1016/j.algal.2019.101750

Rengasamy, K. R., Mahomoodally, M. F., Aumeeruddy, M. Z., Zengin, G., Xiao, J., & Kim, D. H. (2020). Bioactive compounds in seaweeds: An overview of their biological properties and safety. Food and Chemical Toxicology, 135, 111013. https://doi.org/10.1016/j.fct.2019.111013

Ripol, A., Cardoso, C., Afonso, C., Varela, J., Quental-Ferreira, H., Pousão-Ferreira, P., & Bandarra, N. M. (2018). Composition, Anti-inflammatory Activity, and Bioaccessibility of Green Seaweeds from Fish Pond Aquaculture. Natural Product Communications, 13(5), 1934578X1801300. https://doi.org/10.1177/1934578X1801300521

Rohani-Ghadikolaei, K., Abdulalian, E., & Ng, W.-K. (2012). Evaluation of the proximate, fatty acid and mineral composition of representative green, brown and red seaweeds from the Persian Gulf of Iran as potential food and feed resources. Journal of Food Science and Technology, 49(6), 774–780. https://doi.org/10.1007/s13197-010-0220-0

Rupérez, P., Gómez‐Ordóñez, E., & Jiménez‐Escrig, A. (2013). Biological Activity of Algal Sulfated and Nonsulfated Polysaccharides. In Bioactive Compounds from Marine Foods (pp. 219–247). Wiley. https://doi.org/10.1002/9781118412893.ch11

Seong, H., Bae, J.-H., Seo, J. S., Kim, S.-A., Kim, T.-J., & Han, N. S. (2019). Comparative analysis of prebiotic effects of seaweed polysaccharides laminaran, porphyran, and ulvan using in vitro human fecal fermentation. Journal of Functional Foods, 57, 408–416. https://doi.org/10.1016/j.jff.2019.04.014

Škrovánková, S. (2011). Seaweed Vitamins as Nutraceuticals (pp. 357–369). https://doi.org/10.1016/B978-0-12-387669-0.00028-4

Suganya, S., Ishwarya, R., Jayakumar, R., Govindarajan, M., Alharbi, N. S., Kadaikunnan, S., Khaled, J. M., Al-anbr, M. N., & Vaseeharan, B. (2019). New insecticides and antimicrobials derived from Sargassum wightii and Halimeda gracillis seaweeds: Toxicity against mosquito vectors and antibiofilm activity against microbial pathogens. South African Journal of Botany, 125, 466–480. https://doi.org/10.1016/j.sajb.2019.08.006

Susanto, Fahmi, Hosokawa, & Miyashita. (2019). Variation in Lipid Components from 15 Species of Tropical and Temperate Seaweeds. Marine Drugs, 17(11), 630. https://doi.org/10.3390/md17110630

Tanna, B., Brahmbhatt, H. R., & Mishra, A. (2019). Phenolic, flavonoid, and amino acid compositions reveal that selected tropical seaweeds have the potential to be functional food ingredients. Journal of Food Processing and Preservation, 43(12). https://doi.org/10.1111/jfpp.14266

van Wyk, A. S., & Prinsloo, G. (2020). Health, safety and quality concerns of plant-based traditional medicines and herbal remedies. South African Journal of Botany, 133, 54–62. https://doi.org/10.1016/j.sajb.2020.06.031

Vatsos, I. N., & Rebours, C. (2015). Seaweed extracts as antimicrobial agents in aquaculture. Journal of Applied Phycology, 27(5), 2017–2035. https://doi.org/10.1007/s10811-014-0506-0

Woo, C. S. J., Lau, J. S. H., & El-Nezami, H. (2012). Herbal Medicine: Toxicity and Recent Trends in Assessing Their Potential Toxic Effects. In L. F. Shyur & A. S. Y. Lau (Eds.), Advances in Botanical Research (pp. 365–384). Elsevier Ltd. https://doi.org/10.1016/B978-0-12-394591-4.00009-X

Zava, T. T., & Zava, D. T. (2011). Assessment of Japanese iodine intake based on seaweed consumption in Japan: A literature-based analysis. Thyroid Research, 4(1), 14. https://doi.org/10.1186/1756-6614-4-14

Zbakh, H., Salhi, G., Bochkov, V., Ciudad, C. J., Noé, V., Hassoun, M., & Riadi, H. (2020). Insights on the anti-inflammatory and antitumor activities of extracts from the marine green alga Codium decorticatum. European Journal of Integrative Medicine, 37, 101170. https://doi.org/10.1016/j.eujim.2020.101170

Đăng ký/Đăng Nhập
Tìm kiếm